文章：

1. Yakun Yi+, Peng Song+, Ziyi Li, Jinzhou Ju, Guixiang Sun, Qianyuan Ren, Ke Zhou, Lei Liu,* Hai-Chen Wu* Nanopore-based enzyme-linked immunosorbent assay for cancer biomarker detection, Nature Nanotechnology, 2025, DOI: 10.1038/s41565-025-01918-z.

2. Qianyuan Ren⁺, Wenying Hao⁺, Lixia Wang, Ke Zhou, Lei Liu,* and Hai-Chen Wu* ,CH−π Interactions Elucidated at the Single-Molecule Level, J. Am. Chem. Soc. , 2025, DOI: 10.1021/jacs.5c12708.

3. Xueshuang Wu⁺, Wenying Hao⁺, Shuaihu Yan, Ke Zhou, Lei Liu,*and Hai-Chen Wu*, Selective Nanopore Detection of Monoamine Oxidase A and B in a Single Sample, Angewandte Chemie International Edition, 2025, e202505138.

4. Ziyi Li, Yakun Yi, Yun Zhang, Yuanyuan Xiao, Qianyuan Ren, Ke Zhou, Lei Liu,* Hai-Chen Wu*, Nanopore-Based High-Resolution Detection of Multiple Post-Translational Modifications in Protein , Angewandte Chemie International Edition, 2025, e202423801.

5. Shuaihu Yan, Jianchuan Liu, Lei Liu,* and Hai-Chen Wu*，Formation of Non-Amphiphilic Vesicles in Organic Solvents, Small, 2025, 2503015.

6. Yakun Yi, Ziyi Li, Lei Liu,* and Hai-Chen Wu* ,Towards Next Generation Protein Sequencing, ChemBioChem, 2025, 26, e202400824.

7. Yun Zhang, Yakun Yi, Ziyi Li, Ke Zhou, Lei Liu,* Hai-Chen Wu*, Peptide sequencing based on host–guest interaction-assisted nanopore sensing, Nature Methods, DOI:10.1038/s41592-023-02095-4

8. Weichao Peng, Shuaihu Yan, Ke Zhou, Hai-Chen Wu*, Lei Liu* ,Yuliang Zhao， High-resolution discrimination of homologous and isomeric proteinogenic amino acids in nanopore sensors with ultrashort single-walled carbon nanotubes , Nature Communications, 2023, 14:2662

9. Yingying Sheng, Ke Zhou, Lei Liu,* and Hai-Chen Wu*, A Nanopore Sensing Assay Resolves Cascade Reactions in a Multienzyme System, Angewandte Chemie International Edition, 2022, e202200866  

10. Lei Liu+, Yi You+, Ke Zhou, Bingyuan Guo, Zhong Cao, Yuliang Zhao, and Hai-Chen Wu*, A Dual-Response DNA Probe for Simultaneously Monitoring Enzymatic Activity and Environmental pH Using a Nanopore, Angewandte Chemie International Edition, 2019, 58, 14929 –14934.

11. Bingyuan Guo, Yingying Sheng, Ke Zhou, Quansheng Liu, Lei Liu*, and Hai-Chen Wu*, Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing, Angewandte Chemie International Edition, 2018, 57, 3602 –3606.

12. Lei Liu*, Ting Li, Shouwen Zhang, Peng Song, Bingyuan Guo, Yuliang Zhao and Hai-Chen Wu*, Simultaneous Quantification of Multiple Cancer Biomarkers in Blood Samples through DNA-Assisted Nanopore Sensing, Angewandte Chemie International Edition, 2018, 57, 11882 –11887.

13. Lei Liu, Hai-Chen Wu*, DNA-Based Nanopore Sensing, Angewandte Chemie International Edition, 2016, 55, 15216 –15222.

14. Ting Li+, Lei Liu+, Yuru Li, Jiani Xie, Hai-Chen Wu*, A universal strategy for aptamer-based nanopore sensing through host-guest interactions inside α-hemolysin, Angewandte Chemie International Edition, 2015, 54(26):7568-7571.

15. Lei Liu, Jiani Xie, Ting Li, Hai-Chen Wu*, Fabrication of nanopores with ultrashort single-walled carbon nanotubes inserted in a lipid bilayer，Nature Protocols, 2015, 10(11):1670-1678.

16. Lei Liu，Chun Yang，Kai Zhao，Jinyuan Li，Hai-Chen Wu*，Ultrashort single - walled carbon nanotubes in a lipid bilayer as a new nanopore sensor, Nature Communications, 2013, 4: 2989.

主持项目：

• 四川省天府峨眉创新领军人才项目，基于纳米孔技术的单分子分析方法，2024 - 2029，100万。

• 国家自然科学基金面上项目，22374151，基于纳米孔和CRISPR技术对癌症基因突变位点的检测研究，2024.01- 2027.12, 50万元。

• 国家自然科学基金面上项目，21874136，纳米孔单分子技术应用于端粒酶活性检测的研究，2019.01- 2022.12, 65万元。

• 国家自然科学基金面上项目，21475132，纳米孔单分子检测技术应用于8-羟基鸟嘌呤的检测研究，2015.01- 2018.12，85万元。

• 国家自然科学基金委青年基金项目，21205119，纳米孔单分子检测技术应用于水体中重金属离子的检测研究，2013.01- 2015.12，25万元。

1. 四川省天府峨眉创新领军人才；

2. 湖南省自然科学三等奖。